what is factor 5 Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism A mutation in your F5 gene causes this disorder which follows an autosomal dominant inheritance pattern Most people with this disorder never develop a blood clot
Factor V Leiden is an inherited condition caused by a specific genetic mutation in the factor V gene This gene is responsible for producing a protein called factor V which plays a crucial role in the clotting system Factor V factor 5 is one of several special proteins in your blood that help it clot They re called clotting factors Once the bleeding stops other proteins tell your clotting
what is factor 5
what is factor 5
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Having factor V Leiden means that you have a greater chance of developing a dangerous blood clot in your legs DVT or lungs PE About 1 out of 10 000 people will develop a DVT or PE each year Factor V Leiden is an autosomal dominant genetic condition that exhibits incomplete penetrance i e not every person who has the mutation develops the disease The condition results in a factor V variant that cannot be as easily degraded by activated protein C The gene that codes the protein is referred to as F5
Structure Factor V protein consists of six domains A1 A2 B A3 C1 C2 The A domains are homologous to the A domains of the copper binding protein ceruloplasmin and form a triangular as in that protein A copper ion is bound in the A1 A3 interface and A3 interacts with the plasma 6 For factor V Leiden some basic questions to ask your doctor include What kinds of tests do I need Do I need to see a specialist Does my factor V Leiden need to be treated Do I need to take medication to prevent additional blood clots What types of side effects can I expect from the medication Do I need to limit my activity in any way
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Factor V factor five is a protein involved in the blood clotting process Children born with Factor V Leiden produce a mutated form of Factor V that does not respond well to activated Protein C This may lead to abnormal clot Factor V Leiden is the name of a specific gene mutation that results in thrombophilia which is an increased tendency to form abnormal blood clots that can block blood vessels People with factor V Leiden thrombophilia have a higher than average risk of developing a type of blood clot called a deep venous thrombosis DVT
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