what is the half life of spironolactone 25 mg Spironolactone has a half life of 1 4 hours For those who have cirrhosis a form of chronic liver damage this medication has a higher half life of 9 hours
Liver biliary A very few cases of mixed cholestatic hepatocellular toxicity with one reported fatality have been reported with spironolactone administration Spironolactone Tablets USP 25 mg are white film coated round tablets debossed AN above 511 on one side and plain on other side
what is the half life of spironolactone 25 mg
what is the half life of spironolactone 25 mg
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The mean half life of spironolactone is 1 4 hour The mean half life values of its metabolites including canrenone 7 thiomethyl spirolactone TMS and 6 hydroxy 7 thiomethyl The dose of this medicine will be different for different patients
Chronic heart failure with reduced ejection fraction nyha class iv Men specifically may experience gynecomastia loss of libido and general feminization the drug is a category C pregnancy drug because animal studies showed that the feminization of male fetuses is a concern
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The recommended initial daily dosage is 100 mg of spironolactone tablets administered in either single or divided doses but may range from 25 to 200 mg daily 1 1 Heart Failure Spironolactone is indicated for treatment of NYHA Class III IV heart failure and reduced ejection fraction to increase survival manage edema and reduce
Although the plasma half life of spironolactone itself is short 1 3 hours the half lives of the active metabolites are longer ranging from 2 8 to 11 2 hours Elimination of metabolites occurs Typically your doctor will start you on a low dosage and adjust it over time to reach the dosage that s right for you
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what is the half life of spironolactone 25 mg - Chronic heart failure with reduced ejection fraction nyha class iv