img 7289 Lysine specific demethylase 1 LSD1 is a histone demethylase critical for self renewal potential of malignant stem cells and progenitor maturation Bomedemstat is an oral LSD1 inhibitor clinically active in patients with MPNs IMG 7289 CTP 102 is a global open label Phase 2 study evaluating bomedemstat dosed in MF patients NCT03136185
IMG 7289 CTP 201 is a global open label Phase 2b study of bomedemstat taken once daily for 24 weeks in patients with ET who are resistant to or intolerant of at least one SOC treatment NCT04254978 IMG 7289 CTP 102 is a global open label Phase 1 2 study evaluating bomedemstat dosed once daily in MF patients NCT03136185 Data from this ongoing study are presented
img 7289
img 7289
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IMG 7289
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IMG 7289
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IMG 7289 CTP 201 is an ongoing global open label Phase 2b study of bomedemstat taken QD for 24 weeks in patients with ET who are resistant intolerant to at least one standard treatment NCT04254978 Aims IMG 7289 CTP 102 is an ongoing global open label Phase 2 study evaluating bomedemstat dosed QD in MF patients NCT03136185 Key eligibility criteria include patients intolerant refractory resistant or inadequately controlled by approved therapy and platelet count 100 x 109 L Key objectives are safety and reduction of spleen
IMG 7289 CTP 201 was a global open label Phase 2b study of bomedemstat IMG 7289 MK 3543 taken once daily for 24 weeks in patients with ET resistant to or intolerant of at least one standard treatment NCT04254978 A phase 2 study of bomedemstat IMG 7289 a lysine specific demethylase 1 LSD1 inhibitor for the treatment of later stage myelofibrosis MF Presented at 2020 European Hematology
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This is a Phase 2b open label study of an orally administered LSD1 inhibitor Bomedemstat MK 3543 formerly called IMG 7289 in patients with essential thrombocythemia This study investigates the following The safety and tolerability of Bomedemstat The pharmacodynamic effect of Bomedemstat IMG 7289 CTP 102 is an ongoing multi national open label 24 week Phase 2 study of IMG 7289 taken once daily in MF patients resistant to all approved therapies Key objectives are safety and reduction a in spleen volume
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