14 3 3 proteins structure function and regulation 14 3 3 proteins are a family of structurally similar phospho binding proteins that regulate essentially every major cellular function Decades of research on 14 3 3s have
This review examines the structural basis for 14 3 3 ligand interactions proposed functions of 14 1 3 in various signaling pathways and emerging views of mechanisms that regulate 14 2 3 The 14 3 3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells A striking feature of the 14 3 3 proteins is their ability to bind a multitude of
14 3 3 proteins structure function and regulation
14 3 3 proteins structure function and regulation
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The crystal structure of the Nth1 14 3 3 complex the first example of a 14 3 3 complex with a multidomain partner demonstrated the ability of 14 3 3 proteins to modulate interdomain In this minireview we focus on mechanisms of the 14 3 3 protein dependent regulation of three important 14 3 3 binding partners yeast neutral trehalase Nth1 regulator of G protein
A wide spectrum of functions has been ascribed to these proteins including the following roles in transcriptional regulation in plants 1 cell cycle controls for DNA damage in fission yeast 2 and inhibitors or activators of protein kinase Functions of 14 3 3 proteins in survival and apoptotic signaling Regulating the balance between survival and apoptotic signaling is a key aspect of cell fate decisions and 14 3 3 proteins
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Several distinct mechanisms of the 14 3 3 protein function were described including conformational modulation of the bound protein masking of its sequence specific or structural In this review we examine the structural basis for 14 3 3 ligand interactions proposed functions of 14 3 3 in various signaling pathways and emerging views of
The 14 3 3 proteins are a family of highly conserved proteins found in lower and higher eukaryotic cells Mul tiple isoforms have been found in mammalian cells Mammalian brain PTMs are key factors regulating LLPS 14 3 3 proteins could modulate LLPS of their binding partners by facilitating the occurrence of PTMs by recruiting enzymes Mode III in Fig 3b In
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14 3 3 proteins structure function and regulation - A wide spectrum of functions has been ascribed to these proteins including the following roles in transcriptional regulation in plants 1 cell cycle controls for DNA damage in fission yeast 2 and inhibitors or activators of protein kinase