14 3 3 proteins a number of functions for a numbered protein

14 3 3 proteins a number of functions for a numbered protein The effects of 14 3 3 proteins on their targets can be broadly defined using three categories i conformational change ii physical occlusion of sequence specific or structural protein

Structure and Function The 14 3 3 proteins are small 30 kD acidic proteins that form both homo and heterodimers The number of isoforms found in various organisms ranges from 2 This minireview focuses on mechanisms of the 14 3 3 protein dependent regulation of three important 14 3 3 binding partners yeast neutral trehalase Nth1 regulator of G protein signaling 3 RGS3 and phosducin

14 3 3 proteins a number of functions for a numbered protein

14 3 3 proteins a number of functions for a numbered protein
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This review summarizes our current knowledge of 14 3 3 proteins and describes some exciting new developments in this field Readers are directed to several excellent reviews on 14 3 3 function for further information 17 23 Structure and Function The 14 3 3 proteins are small The 14 3 3 proteins are a family of ubiquitously expressed exclusively eukaryotic proteins with an astonishingly large number of binding partners Consequently 14 3 3s modulate an enormous and diverse group of cellular processes

14 3 3 belongs to the 14 3 3 protein family which is a class of highly conserved proteins involved in regulating signal transduction pathways apoptosis adhesion cellular The 14 3 3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells A striking feature of the 14 3 3 proteins is their ability to bind a multitude of functionally diverse signaling proteins including kinases phosphatases and transmembrane receptors

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This STKE Review with 2 figures 1 interactive molecular structure and 118 references describes 14 3 3 proteins and highlights how these simple proteins have profound effects on the regulation of a vast number of cellular events Europe PMC is an archive of life sciences journal literature

14 3 3 proteins play a crucial role in cellular signaling with a wide range of functions 14 3 3 proteins as conserved entities involve in various biological processes including mitotic 14 3 3 proteins constitute a family of eukaryotic proteins that are key regulators of a large number of processes ranging from mitosis to apoptosis 14 3 3s function as dimers and bind to particular motifs in their target proteins

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14 3 3 proteins a number of functions for a numbered protein - The 14 3 3 proteins are a family of ubiquitously expressed exclusively eukaryotic proteins with an astonishingly large number of binding partners Consequently 14 3 3s modulate an enormous and diverse group of cellular processes